| ncRNA name | CANT1 |
| ncRNA Category | lncRNA |
| ID | 124583 |
| Ensembl | ENSG00000171302 |
| Synonyms | SCAN-1, SHAPY |
| Disease name | uveal melanoma (UM) |
| Species | Homo sapiens |
| Tissues/Cell_line | UM cell lines MUM2B, 92.1, OCM1, OCM1A, OM431 and SP6.5; human embryonic kidney cell line HEK293T; RPE cell line ARPE19; female uveal tissue cell line FPC1 |
| Methods | RT-PCR, qRT-PCR, transwell assay, xenograft, microarray, RNA FISH, ChOP, CHIP |
| Expression pattern | down-regulated |
| Functional description | CANT1 triggers the expression of JPX and FTX by directly binding to their promoters and promoting H3K4 methylation.CANT1 significantly reduced tumor metastatic capacity and tumor formation, either in cell culture or in animals harboring tumor xenograft. |
| PubMed ID | 28330694 |
| Year | 2017 |
| Title | CANT1 lncRNA Triggers Efficient Therapeutic Efficacy by Correcting Aberrant lncing Cascade in Malignant Uveal Melanoma. |
| Drug-related ncRNA | NO |
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